Testicular cancer and infertility

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Spermatogonial stem cells, infertility and testicular cancer

The spermatogonial stem cells (SSCs) are responsible for the transmission of genetic information from an individual to the next generation. SSCs play critical roles in understanding the basic reproductive biology of gametes and treatments of human infertility. SSCs not only maintain normal spermatogenesis, but also sustain fertility by critically balancing both SSC self-renewal and differentiat...

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Infertility in patients with testicular cancer: testis, tumor, or treatment?

The adult testis functions as both an exocrine and an endocrine gland producing spermatozoa and testosterone. Spermatogenesis is a dynamic and complex process divided into three phases: (a) proliferation of spermatogonia to produce spermatocytes and to renew the germ cell pool, (b) meiotic division of spermatocytes to reduce by half the chromosome number in the germ cells, and (c) maturation of...

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Chemotherapy-induced infertility in patients with testicular cancer.

A 29-year-old Caucasian married man, Mr. A, is the father of a 1-year-old daughter and is a successful tax attorney who maintains a healthy lifestyle. While performing a testicular self-examination, Mr. A noticed a small, fixed mass in his left scrotum. After medical workup, biopsy, and consultation, a left orchiectomy and retroperitoneal dissection were recommended. Pathology revealed a nonsem...

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Detection of testicular cancer in men presenting with infertility.

PURPOSE Infertility is one of the less common presenting features associated with testicular tumors. We evaluated the histologic and biochemical findings, and pregnancy outcome in patients presenting with infertility who were found to have testicular tumors. METHODS Seven patients with infertility were found to have testicular cancer over a 15-year period. All patients had a testicular ultras...

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Testicular Biopsy in Male Infertility

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ژورنال

عنوان ژورنال: BMJ

سال: 2000

ISSN: 0959-8138

DOI: 10.1136/bmj.321.7264.781